Florastor is a yeast. Culturelle has one strain of a "good bacteria". Align has a different one - one strain I believe, maybe two. Some are multi-strain, like the ones I take VSL#3 and others like PB8. Since Florastor is a yeast, you can certainly take a bacterial strain probiotic as well like Culturelle or any other one. They give people gas and bloating often, so if you decide to start one, go slowly. Or try the kefir, as it has the bacterial strains in it too. Your pharmacist can probably give you more information.